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If you're addicted, you may feel unable to quit using the drug.
Dependence is when your body learns to depend on a drug.
This is accomplished along a continuum of sedation levels: Prior to the administration of medications, clinicians must know the level of sedation required for a given procedure and the appropriate dose of the pharmacologic agent or agents chosen.
This determines the equipment that one should have readily available prior to starting the procedure.
The intravenous route is emphasized in the discussion below.
The benzodiazepines act by stimulating specific benzodiazepine receptors in the CNS.
The medications below are presented according to pharmacologic class.Cardiovascular depression, resulting in hypotension with reflex tachycardia, is another adverse effect, but it is not significant at typical doses unless hypovolemia is present or unless it is coadministered with centrally acting analgesics.Be cautious when giving a hepatically metabolized benzodiazepine (eg, midazolam) to a patient with cirrhosis.Stimulation of this receptor potentiates the inhibitory effects of gamma-aminobutyric acid (GABA) on GABA-A receptors.
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This results in chloride influx, hyperpolarization, and decreased ability of the neuron to reach an action potential, producing sedation and anxiolysis.In nonintubated patients, the desired effect is found by titration until the desired effect is achieved.
